Odorant/Pheromone Binding Proteins

OBPs, members of lipocalin protein family, are highly diverse, small, water-soluble, globular, ligand specific proteins present in the mucus fluid produced by nasal glands in vertebrates and in the sensillar lymph in insects. OBPs act a “carrier” to transport odorants across the hydrophilic mucus layer and release them in vicinity of their respective ORs. OBPs are highly selective, as they have unique ligand binding profile. OBPs functionality and expression are not limited to olfaction mechanism and olfactory organs. They are found to be involved in various other functions like measuring odorant concentration, deactivating odorants, etc. and found in taste organs, venom glands, sex hormone glands, etc of insects. Structurally OBPs are made up of eight antiparallel β-sheets folded into a continuous hydrogen-bonded β-barrel and a α-helical domain at the carboxyl terminal. OlfactionBase comprises of 2418 Odorant binding proteins, 399 Pheromone Binding proteins and 14 receptors from 189 species.

obp
Sr. No UniProt Organism Type Length Sequence
126 B0XD54 Culex quinquefasciatus Odorant binding 119 MTTAEITDKEKAYVHRYFVECEASLNMSLGVNIENRMEHGEQVVGDAQFKKFIFCFMTRTGFVKPDGSFNKQAFIDVLKDGYDPAATDSMVDKCYNYTIKSVEERIYQQYKCMFANHFY
127 B3N165 Drosophila ananassae Odorant binding 119 MAVPRHSLVCLSFLLSFTICFAAEDCLKVYNLTSKKVESVPPSTPVSEVPHNIKCYSRCIIDEYFGDDDKIDLKRLENRARDDEKVILADCKQKYDDDSSDRCDYAYKIIQCLYLGRVN
128 B4IMQ5 Drosophila sechellia Odorant binding 119 MKVFIVFAALAALSVASAAGLTDSQKAEAKQRAKACAKQEGITKEQACVKCFANCFLEQSGLVANGQIKPDVVLAKLGPIAGEANVKEVQAKCDSTKGADKCDTSYLLYKCYYENRAQI
129 D6WRD1 Tribolium castaneum Odorant binding 119 MKQIYCLITVVVLIPTLTALENEGQNPDTANCVALGGQRIKDSEIAKMAHCILTKTNLMTDKGTFNSNLLKERLRQSVHSDELVDKVVMMCTVEKETPLKSAFSGYKCLRYLVPWFPLD
130 D6WS45 Tribolium castaneum Odorant binding 119 MQKILFLGLFVSSSLSTRFFNHDEIQKLECFPDIGGGLKAELWPNVVSCVFHRKGFTDDKGEFKIDVLKQKLSKFQDDKYLVNEIAELCVDKHDFTMTAAMKSALCLNKHAPWFSPYQD
131 G8B1S1 Nasonia vitripennis Odorant binding 119 MKSVLVVFAAICIAGVLSDPKGDIDACVAESKVDTKLFEDMMHTPDFKATREMDCFAACMFKKDGVLDADGNVDASKLPNVDVSKVCGALRGKDACETAGKIIGCFAEKGVMDVFHIV
132 T1GKE5 Megaselia scalaris Odorant binding 119 MRKVYFINFLILSCLVNEIYSITMDQFMKSLDMMRNGCTVKFPKVPVEDLDKFRSGVLPDNITKDFKCYTKCVAQLGGVLTKKGEISVQKSLAQMLIIIPKEMHETTGAAINACSEKNL
133 A0A0L7KZC7 Operophtera brumata Odorant binding 120 MECNKQHPISPEEMMMMKDHKMPDSENAKCLMACVMRKATFIDDKGNFSVENAIAWAGKEFQDEPKRLESSKSIYDICKKVNDEPVSDGEKGCDRAFLLSKCLIENAPKVTLLSRYPYNT
134 A0A0M3QVE6 Drosophila busckii Odorant binding 120 MHFVTQLCILLSIAMVMGSPKEYELECMKAAQNISEHEIADGIVNPKKDSNGVDKRIKCFLDCIFKSLGITSGQSFIEKMPSDAGSINDGTEVIKCWDKQTQGDDCQRAYEFVLCLRFVI
135 A0A146M998 Lygus hesperus Pheromone binding 120 MSQAQMKQAMKTVRNMCIPKSGVAKEALAKMVEGEFDDSDQKLKCYLGCVLGMMQAVKNNKINLTMVRNQISKMLAPEQGQRILTAFEGCATVTGDDNCDLAFKFAKCIYDTDKEAFIVP
136 A0A182N0X3 Anopheles dirus Odorant binding 120 MNRFLILSAVVACLAGTSQALGKYEPLPHYVTLKSYQEAQAECAVYLQVPDDRLQRYLREGYPDEPEVHCLVLCVLENLRAWQNGTLQEHVLANYFNLLGQPVCFCTKGKTCPLHRCYGR
137 A0A1B0C1L7 Glossina palpalis gambiensis Odorant binding 120 MEQREKKNFHLTISAFCKLILCLSVFCFAEAIKEFSDGEVHEDEALKCYMNCFFHELGAVDDKGDVHLETLNLIMPGSFVDAILKPAQHCIHPEGDTLCHKAWWFHQCWKKADPEHYFLL
138 A0A1I8QE39 Stomoxys calcitrans Odorant binding 120 MIKVILFLLTYITVLVAADDLQKGQITDCPEMRSLLLCTAKGMNVYSSEKGFDPDRLAYSLYRASNRQCNRELVRECVEQYKNVEPEDAMIFKVIKCIVEQEWDKKYEGLSHPTWQGGCD
139 A0A2A4ITG4 Heliothis virescens Odorant binding 120 NVSLPPKQNEKANQIASECIKESGLKPEVLAEAKKGHISDDEHLKKFTFCFFKKAGIVSEDGKLNVDVALAKLPPGVDKAEAEKLLETCKAKSGKDATETVFEIFKCYHHGTKTHILLGF
140 A0A4C1UMG9 Eumeta variegata Odorant binding 120 MTYNRISEALDVIKEEHTMPGERRRNKREVPFTHDEKRIAGVDGFGFPTLEGLVNLYSEGVNERGYFMTVLESTRECLLKHHDKFSRTTPMDNGRNCDVSFDIFECISDRIGEYCGNTGL
141 B0X9J5 Culex quinquefasciatus Odorant binding 120 MFSFRMTVLKILHNHIDGCVSDLGIKDFDKRELLADAGRQPAPSESFVKILHCLFLSADFVSCDGTVQGDNFAAFIADGHNNMDQLPAALKSCVDGLKGTPEERSFQLYRCMFGQHKFEM
142 E2C4J7 Harpegnathos saltator Pheromone binding 120 MTMEQIEKTAATLRNTCVSKVNANMDTVLAIQKGEFPDDRSLKCYTHCIMKTIRTYKNGRVDEGMMLKQLDLMMPADIAVLMKETTKICAAEPPTGDDCETTFNFVKCSYNNDPDHFFFP
143 Q5TN66 Anopheles gambiae Odorant binding 120 MGRLDLVCLLAIVLLVHSCVSIAWKPSVFESLRAGNFSVRNSLVECFGECFVKRAGFMNDNFTFNRDTIMRFTNRFVSKEISEKVYNICTDNVTPTYCVTAFDVYQCIYENVYKSWDSRK
144 A0A151WKD0 Trachymyrmex zeteki Pheromone binding 121 MKCDSWATLLLTVLIWYAKFCGHDCVDILEEAKKGVFPNEKNFKCYVSCLLDMMQATKRGKISYEKSLKQIDTLLPDDFKPDFRNGLEACKDVAQGVKDHCESAYVLLNCFYQNNPKFIFP
145 A0A154P6G1 Dufourea novaeangliae Pheromone binding 121 ADPDDFRKLTASVRAKCIEETKTTLQAIEDTEFGEFPEDDRLKCYFKCVLEKSSMMDKNGKIKYNLLKKIIPDVYKDVVHGMIDSCTEVTAKDHCEKAYGFMKCLYAENPMVSRTKLRSYR
146 A0A154PP87 Dufourea novaeangliae Odorant binding 121 AVSQEQMEKIAKSMRNACLQKIDTTEELVAGIKRGEFPDDPNLECYTHCIMKTMRSFKNNEIDFKMVMKQIDASMPPDMAPRVKAAVRLCKNREYDTEPCKMTYQYTKCVYEADPEVFFFP
147 A0A182FI13 Anopheles albimanus Odorant binding 121 HPKDCCVLPSLIEESLLQNCKTLHGGEPLQRTLIYERGKCFIECAMNATGTMANGQLDQERILELIEGGTRDDPSLMQLFQSNTLHCAQSANKKRLEQQIRTGCSSLAVDFVGCVNILNFL
148 A0A182RI06 Anopheles funestus Odorant binding 121 TISQEQLEKTAKTFRQVCQPKHKISDAVADDVNRGVFADTKDFKCYVSCLLDIMQVARKGKVNYEKSLKQIDTMLPENMKPAFRAGLDACKSAALGVKDHCDAAAILLQCFYKNNPMFVFP
149 A0A182SJH1 Anopheles maculatus Odorant binding 121 SISQEQLEKTARTFRQVCQPKHKISDAVADDVNRGVFAETKDFKCYVSCLLDIMQVARKGKVNYEKSLKQIDTMLPDNMKPAFRAGLEACKTAAQGIKDHCEAAAILLQCFYKNNPMFVFP
150 A0A194PH26 Papilio xuthus Odorant binding 121 MTRQQLKNSGKIMKKSCMPKNDVTEEQVGEIENGKFLEDRNVMCYIACVYSMSQIVKNNKLNYEAVIKQVDVMFPAEMRDAVKAAAANCKDVGKKYKDICEASYWTAKCMYDFDPKNFVFP
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