Odorant/Pheromone Binding Proteins

OBPs, members of lipocalin protein family, are highly diverse, small, water-soluble, globular, ligand specific proteins present in the mucus fluid produced by nasal glands in vertebrates and in the sensillar lymph in insects. OBPs act a “carrier” to transport odorants across the hydrophilic mucus layer and release them in vicinity of their respective ORs. OBPs are highly selective, as they have unique ligand binding profile. OBPs functionality and expression are not limited to olfaction mechanism and olfactory organs. They are found to be involved in various other functions like measuring odorant concentration, deactivating odorants, etc. and found in taste organs, venom glands, sex hormone glands, etc of insects. Structurally OBPs are made up of eight antiparallel β-sheets folded into a continuous hydrogen-bonded β-barrel and a α-helical domain at the carboxyl terminal. OlfactionBase comprises of 2418 Odorant binding proteins, 399 Pheromone Binding proteins and 14 receptors from 189 species.

obp
Sr. No UniProt Organism Type Length Sequence
26 A0A1W4WCJ1 Drosophila ficusphila Odorant binding 109 MKVLGALLLLLFIDSIFCGKNYFGLDKQFPNCTTLDEALNEMTKPYQQNPSTKKCFYNCVFEKSKMIANGKIVKEYFKEKLKKVKPCLSIEDSNRCELAFKLYECLAKL
27 T1H1C2 Megaselia scalaris Odorant binding 109 MTETGATDDDLKEMIADKLASTKEGKCLKSCLMIRFKSMDDNGKLNKEGSLHIAKEITKNNEKIMELAGQILDACADLGVSADKCEAAEEYSECMIKKAKDLGLKEMVF
28 A0A084WHM8 Anopheles sinensis Odorant binding 110 MKKAEGFALGCLEQHKSLNKEHLLLLKDGDFSKVDADTKCFLRCFLQEAKFMDASGKLQSDYAIERLSLSREKSKVEELVKKCSVTEGEDSCETAFKAVECYHREKASLL
29 A0A182QCU4 Anopheles farauti Odorant binding 110 MLDKQMCFVECAFTNMGALKENDVIDPEPLYTYYARFDSSYREVVVKAISSCANIQDVIRQDVKDMGTSCSAFALVFHLCVAQLTLKNCPADRWKSSLLCNKLRAGVPSC
30 A0A212FEF9 Danaus plexippus plexippus Odorant binding 110 MAELAKMLRDNCLEETGADVALIDKVNQGATLMPDGKLKCYIKCVMETAGMMSGGEVDVEAVVAVLPEELQRHADTMRACGTKRGLDDCDTAFLTQACWQAGCPKDYILI
31 B4J333 Drosophila grimshawi Odorant binding 110 MHARCMSTTGLSEELMNEAHKGKLPSDQTFKCFLHCMFDMFGLVDHNNDMHLDSLLEVLPPEIHPNIKKLADACDMKKGADGCDTVYQAVLCYLETDGAFIADAMNDLLG
32 E2B4Y1 Harpegnathos saltator Pheromone binding 110 MLEMVQGDKERCMAEHGTSQDLIDQVNDGHLSDDRSITCYMNCLLDAFSLVDEEGDLEADMLISVIPEQYQEIGTKLLTKCAKQDGADPCEKIFKVAQCVQGTVPEVSKL
33 H9JG27 Bombyx mori Odorant binding 110 MMRKSCQPKNNVDDEKINPINDGVFIEENEVKCYIACIMKMANTMKNGKLNFEAAMKQADLLLPDEMKEPTKEAIVACRKVADSYKDVCDASFHVTKCIYNHNPSVFFFP
34 A0A0Q9X0Z9 Drosophila willistoni Odorant binding 111 MKLIYQLILFALLINICLGSSQQQRQNCKNQHNVTDNDLAALPATATVADIPKNIKCFLKCVLQPLLIAENRNYDTDKEQKFMRCKEKYENVEDWSGCDYETNIFLCLDWL
35 A0A151JM91 Trachymyrmex cornetzi Odorant binding 111 DDMITIQDLIHDRYKSENQEKLNKNGCVQQCIFQKNGLMEDAEYKVEKMHTTFIEKTNIQPGDKRLERLENCINESKDLTEKCKKAFLFAVCFLKSEQEHMHDYGYSESAK
36 A0A182J8Q5 Anopheles atroparvus Odorant binding 111 MLAFRLACMLETGAREDQITAFNQPEPVPADRELQCYMYCMFRAYNATKPNGDVDVIDVYHAIPKQYNSVALKAIARCQPNIGGEDPCERAYAHHKCWKEIVPDTPQMGLT
37 A0A1I8Q245 Stomoxys calcitrans Odorant binding 111 MEIKNKCQQEVPLTVEEVNKFSADPVKHVTESIQCHLKCMMEKQGMLIDGIFDVAASLKTMETYPAYKNRKSEVVAAVEECKSQSGENNCEIAYKILMCLQAHEAKVFANV
38 A0A1L3KPT1 Cyrtotrachelus buqueti Pheromone binding 111 MFKAKNIALGRRRIHISLFQMLPCTYRSMFLQRLCTVSYTLCHGVLAMVVPVFPSFLSRLPNQENYLVFATYKNSLHIVNNTFLFYLCPKHHHAFHLLVLQLLWFLEYRHF
39 A0A2S0M1B9 Corythucha ciliata Chemosensory 111 MTTLALFHFLLLAVCLSVCLGAETRGTVTDEALESALKDKRYLTRQLKCALGEGACDPVGRRLKTYAPLVLRGACPKCTPTEVRQIQQVLSHIQRHYPKEWSKILKQYAGQ
40 B0WM04 Culex quinquefasciatus Odorant binding 111 MVHFTSREEMRQKCMDQEGATQEDAEAVLKHLKSPESRAQKCFLACIFEHGRTSDGKRFVTEVFLEKGEKMSGNDQERLHSVREAAERCDGVENDDRCELAAEIVACLKDS
41 Q863D3 Sus scrofa Pheromone binding 111 MRLSLTVLLVTLALCCYEAHGIVCRALVKEFSAFLWKPDEIYKPELELFGAPPEAVDAKMKVKQCANGISFKKKILLTKTLVEILVKKCGFEDVKTLFPDISLGLSASVFK
42 A0A084VXC2 Anopheles sinensis Odorant binding 112 MLHEICIAESGASEELLRQCLDGTVHDDPAVKCYIHCLFDKIDVIDEDTGRIVLDRLLYLVPDDVKEAVEHLTRECSHIVTPDKCDTAYQTTKCYFKAHDEVIKFCHLLMLD
43 A0A0L7LD28 Operophtera brumata Odorant binding 112 MAQSCVIKVRATPKDVRAYFTNTTPSARTGQCFAACMLEQSDIINHGKNSRVVRKLNSVSRLCLDSIEGMSDRCQLASTYNDCLNENMTEFAFPLDIAEEAVRKMPFHLIQP
44 A0A151JMK9 Trachymyrmex cornetzi Odorant binding 112 DDMLTVQDVAHDQYKSESQERLNKNGCVMQCLLQKGGMASNAEYKAEKMRSEFIKKTSVQPGDKRLESLDACINESKDLTEKCEKAFLISACFIKGEHKHKHGNEHEHEHEK
45 A0A1L3KPR5 Cyrtotrachelus buqueti Pheromone binding 112 MRVFEIALVYQINGIARVLSFNFTFLHDCEGLFFIGLRRQFGLYDVQLYFALVIHESRLLVETLGETFEGGVFREVSLVRFLDQFRIDFALLNALFTVLEDFLLLLFGEFLA
46 A0A212FAH0 Danaus plexippus plexippus Odorant binding 112 MYAHEKISDMVAQQCLTEMYPKGKKIELQESDESCIIYCVLKKFGIINGNGQFNLDIYRKRVQMAHQLDSRNLMNDKGGACVESAEATQHKQDVCKKAKVFNDCTHLYRMIF
47 A0A6B9RZ70 Helopeltis theivora Pheromone binding 112 MYFWKEDFQVTSREAGCAIFCLSKKMDIIDPEGKLHKGKTNDFLKQHGSDDDTARKVMDILHNCEADAGDNSDDCMRALDVAMCFKKEMHSLNWAPDPEVLLEELMSEMRAQ
48 B4Q5Q5 Drosophila simulans Odorant binding 112 METAEGCIPEVGASDADLQELVKKQPASTYAGKCLRACVMKSFGVLGADGKLDTEAGREKAKQYTGNDPAKLKIALEIGDTCAAITVPDDHCEAAEAYGACFKGEAKKHGLF
49 A0A0L7LD29 Operophtera brumata Odorant binding 113 MYAHDRLSDVIAEQCLNEMYPNVKHVDIQESDESCIIFCVLKKFGIMNSSGVINLEAYRKRVLVARQNEERNSVNDYGGTCIESAEATQHKQDVCKKAKVFNDCTRLYRILLK
50 A0A0N1IDQ2 Papilio machaon Odorant binding 113 MYAHDKASDVVADQCLSEMYPKGKRVEFQESDEACIIYCVLKKFGIMNSNGVINLEAYRKRVLQAHQLDQRKLMSDSSGSSCAESAEGAQHKQDVCKKAKIFNDCTHLYKILL
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