Odorant/Pheromone Binding Proteins

OBPs, members of lipocalin protein family, are highly diverse, small, water-soluble, globular, ligand specific proteins present in the mucus fluid produced by nasal glands in vertebrates and in the sensillar lymph in insects. OBPs act a “carrier” to transport odorants across the hydrophilic mucus layer and release them in vicinity of their respective ORs. OBPs are highly selective, as they have unique ligand binding profile. OBPs functionality and expression are not limited to olfaction mechanism and olfactory organs. They are found to be involved in various other functions like measuring odorant concentration, deactivating odorants, etc. and found in taste organs, venom glands, sex hormone glands, etc of insects. Structurally OBPs are made up of eight antiparallel β-sheets folded into a continuous hydrogen-bonded β-barrel and a α-helical domain at the carboxyl terminal. OlfactionBase comprises of 2418 Odorant binding proteins, 399 Pheromone Binding proteins and 14 receptors from 189 species.

obp
Sr. No UniProt Organism Type Length Sequence
226 A0A232EWX4 Aedes aegypti Odorant binding 126 MKRVLALVGAFLLVSAVQCDDMPFWNEMVECAQGMGISLDQMKSMLTSKDAQMNCVHACVLEKIGGMVDGKLSLDSLMESLEKLKAEVKDYDATKAGIHQCFDQASGDRCESAGQFAMCMQEHMQG
227 A0A2S0M1E6 Corythucha ciliata Chemosensory 126 MAVFGVFLLLALHVLATATAYTTSYDKVDIDNIFKNERLYKKYLECLLDKGPCPPEGKELKTIIPDALATGCEKCTEQQKAGVMKAMKFLIKDHKEDFDLLADLYDKNGEYRKKYQDMAKEHGIEI
228 B0WM01 Culex quinquefasciatus Odorant binding 126 MNILSACIISLIFTSAYSMSDHEAFHACVDQEGPSKKDIEVITKFEAPTTRTQKCFYACLFEQTGTSNGHRFDKERYMKRAKELAGNDQRKLSGFQAVAERCDGVENVDRCDLAADILACLKGSSS
229 B0WU15 Culex quinquefasciatus Odorant binding 126 MNIYCTVGLLATLALVVSVSADEARCMREEGASDVDAQVLRESRPPVTRTQKCFFDCMYRASRFSDGKRFTKDGFIAYVMRVVGHDGLKFQVLSAMADKCVHLESDDRCQLAADIEKCLFGQHRKD
230 B0XAG4 Culex quinquefasciatus Odorant binding 126 MNLISAFGVFLAAAMVSADLSIQEEKCMKEEGATVDDVEAFRAAKMPETRVQKCYYGCLFQALGYLDAEGKRFNSEGFLKTTLPMAANNEKHTQGVHRLAKQCEGVANEDRCELGEDLMACLKDRG
231 B0XC65 Culex quinquefasciatus Odorant binding 126 MFANRSIRCPMVGANSFERINEVLTLILIPSDILEEAKKGVFPNEKNFKCYVSCLLDMMQATKRGKISYEKSLKQIDTLLPDDFKPDFRNGLEACKDVAQGVKDHCESAYVLLNCFYQNNPKFIFP
232 B0XK46 Culex quinquefasciatus Odorant binding 126 MNILSACIIFTIFVSAYSMSDDQAFHACIDQEGPSKEDVKVITKFETPKTRTQNCFYACLFEQTGTSNGHRFDKERFMKRAKEVAGNDQRKLSGFQAVAEKCDGVENVDRCDLAADILACIRGSLG
233 G8B1T7 Nasonia vitripennis Odorant binding 126 MKRVMALVGAFLLVSAVQCDDMPFWNEKVECAQSMGISPDQMTSMLTSNDAQMNCVHACVLEKIGGMVDGKLSLDSLMESLEKLKAEVKDYDATKAGIHQCFDQASGDRCESAGKFAMCMQEHMQG
234 M4VRK6 Dendroctonus ponderosae Odorant binding 126 MTFQGGVSVFLCILGVAQLVAAGNSDDLFARIAPADVEMCGKDTGVDRKEFEDAREKRALNHSMLCFLKCAMEKVGFLKDGHLEIDQAKGSLPDKMMEPVVECFKAVGPISTCDDIQKVEDCLPSS
235 Q0IF98 Aedes aegypti Odorant binding 126 MKQNVLLWIACFSLAFCTCKIRNLQVDGNMPKVKEYMNCAFESSGWTKDGGKKLDTSKVAQDMVPYGFNVKKELDEVTKECETEFGAETSSIDYLACLLIDEKTKTQFKTMLMMKEADFFKQNLCN
236 A0A0L7L5E1 Operophtera brumata Odorant binding 127 MCIKDNLISGEDIANLRAKKVPTGPNSGCFLACVMRQIGIVISLIAGEDIANLRAKKVPTGPNSGCFLACVMRQIGIMDDAGLIQKETALELAKSVFDDDEEIKHKLLKKHGGDRACYGYGMAMYAI
237 A0A182GWY1 Aedes albopictus Odorant binding 127 MCVVGSSFAHLTQKQHETIKDIAIVCARELEITLDDAFLQPGSYEGVLFKDDRKNKQFIACFLTKMGAVSADGKILGDKLLEFMTEDHDDSSLKSTIEKCVAVEGDTLEDRAYNFHKCFWEERMDEL
238 A0A182JEA8 Anopheles atroparvus Odorant binding 127 MQFDAGLQAQLTQEQHDQAKTISESCHEELGGELPEDNFNRMSRERLILTSETAKCHVHCLYTKTGVVNEDGTVNRMGLIEQLRQGNPIEKAERFATLCEKTEGATKCERAYNVYQCYYKHKSSLVD
239 A0A182SQS2 Anopheles maculatus Odorant binding 127 MALLQLVMAATDDIESLIESCSETVQGMTDDLKAQYRANTFPDDSVTHCFVRCIGLTLNLYTDDDGADLEANWQHLGNVGDEASFIANHRACLDERNLQAIENPCDRAYSAFQCLKEEYGMDQTSQT
240 A0A232F3R3 Trichomalopsis sacrophage Odorant binding 127 MKSVLFIFAIVCVVGVFSDDDKKDLTREQILECVAESGVEETKVEDIKLGNQGLETTREIDCFAACVFKKQGIMNEAGVITPDKPMDNEAAKQCVATTGADACDTAGKVLKCFISNNLVSLMDLDDD
241 B4IMQ6 Drosophila sechellia Odorant binding 127 MKVFLLFIFLSAIWLQAFSMKPYEKVKACLKRQLGYNTITANNKLDDKEDSLQSKCFYHCLLEVKGVIANDAISSEQPRKELVKKYGITDTDELEKAEEKCHSAVKATGKCELGYKIFKCYQSITKH
242 D2A670 Tribolium castaneum Odorant binding 127 MILKASIFLILAVATFGAILEDSELMKVVENCVKKTNANESEFSSPNFLETTPSQPALCTAKCLLESLEIVNSEGNINMETLKEYAQPFESPAREAVATCGEEIKSVTTCDDMEKYRKCVEPLIKNS
243 D6X4H6 Tribolium castaneum Odorant binding 127 MKLFILLSLLSVCYARKEWFDKDPQDVAKWQKECFEASGVSMESMNKLPNITLSEDPKLGENAFCLLKKLGFISEDGTLLIEKLRTSLKNQWGDEIANKLVNECARQKSTPQETAHEMFLCIPAKLK
244 G8B1S0 Nasonia vitripennis Odorant binding 127 MKSILFIFAIVCVVGVFSDDDKKDLTREQILECVAESGVDETKVEDIKLGNQGLETTREIDCFAACVFKKQGIMNEAGVITPDKPMDNEAAKQCVATTGADACDTAGKVLKCFISNNLVSLMDLDDD
245 H9IZI1 Bombyx mori Odorant binding 127 MIIILSYSQNVHLAETQKEKAKQYTSECVRESGVSTEAINAAKIGKYSKDKAFKNFVLCFFKKSAIFNSDGTLNMDVALAKLPPGVNKSEAQSVLKQCKNKTGQGAADKAFEIFRCYYKGTKTHILF
246 T1GVU7 Megaselia scalaris Odorant binding 127 MNILFSLLALILIYDSISQDDFSNDPYFDCYFDVANKMGPDADEARISDCADTCYLDKFEAINKNGKLNKEKVWKMINIMVIEDNDQSMVDEFSETFDALIYNCSSLKVLPDKCANGAQYFDCLGTY
247 A0A0N0BFH8 Melipona quadrifasciata Odorant binding 128 MKTLAVIFTFCLVGVLALTEEQKAKLSAHKTACIAEIGVDQQLIEDAKKGIVADDDKLSCFAFCMLKKIGAMTDDGTINVELVRQKLSDGGIPVEKIDNILDKCTDMEGAGNDLLVVAKMDGFRKEES
248 A0A0Q9WW53 Drosophila willistoni Odorant binding 128 MSKAHLIAIVALMAVAINSSPVANNDNVGYHVKKCLEEQNVNPSDISVLNKNIFLFWRIVKCGFHCSAEYHNLIDSNGYLDLEPSSIFENATEIGRKQIKDCQAKLYDTSSDKCDYAWNVLQCAKLLN
249 A0A182MGZ4 Anopheles culicifacies Odorant binding 128 MALLQLVKATDDIGSLIESCSKTVQGMTEELKAGYRTNAFPDDPVTHCFVRCLGLTLNLYDDDKGVDLPANWEHLGKVDDEAQFIAKHRACLDDRNLETIDNPCDRAYSAFQCLKEEYGMDGMDGQKQ
250 A0A182U9A7 Anopheles melas Odorant binding 128 MVQSDTPRRDANYPPPELLEKMKPMHDACVAETGASEDAIKRFSDQEIHEDDKLKCYMNCLFHQAGVVNDKGEFHYVKIQDFLPESMHLITLNWFKRCLYPEGENACEKAFWLNKCWKTRDPVHYFLP
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