Odorant/Pheromone Binding Proteins

OBPs, members of lipocalin protein family, are highly diverse, small, water-soluble, globular, ligand specific proteins present in the mucus fluid produced by nasal glands in vertebrates and in the sensillar lymph in insects. OBPs act a “carrier” to transport odorants across the hydrophilic mucus layer and release them in vicinity of their respective ORs. OBPs are highly selective, as they have unique ligand binding profile. OBPs functionality and expression are not limited to olfaction mechanism and olfactory organs. They are found to be involved in various other functions like measuring odorant concentration, deactivating odorants, etc. and found in taste organs, venom glands, sex hormone glands, etc of insects. Structurally OBPs are made up of eight antiparallel β-sheets folded into a continuous hydrogen-bonded β-barrel and a α-helical domain at the carboxyl terminal. OlfactionBase comprises of 2418 Odorant binding proteins, 399 Pheromone Binding proteins and 14 receptors from 189 species.

obp
Sr. No UniProt Organism Type Length Sequence
176 A0A1A9XY57 Glossina fuscipes Odorant binding 122 MLTALKCFNCLIIGLTGILTTNAITRQQFEQSLVMMRNGCAPKFKLTTEQLDGLRLTKKGELSAQKALAQIPMILPTEMQEVAIASLEHCKDVQKNYKDPCDRMFFITKCVYEFAPDDFTFP
177 A0A1A9YE07 Glossina fuscipes Odorant binding 122 MLNLRLPIIITCLHKGTKMTKIFKGIFLLLGSLLLVAAQNKRNDEKMKKQALKFHNYCTKKVDSNTEYLLAALYNNAEHTEPYKCYLQCIFDTLGLLAKIAATLSTQPRNAITNLNQQREGT
178 A0A226D5I2 Folsomia candida Odorant binding 122 MVFKKQVVLALAATCLVFLALHQQCNARPECIVKCVMGKIGLMDNSSMVSTATVQNFMTTMDIPEEAHDLGHFLAEDCVNEHASKLDPAQPFCESYGDFTMCMQTVFGNFAEKANCQPNLPG
179 B0W4L7 Culex quinquefasciatus Odorant binding 122 MNFVADYNESQKETINKYSDICMKELDFPEDSKILQMAMYGDLSLNDDKSKQFYACMLMKMGFVEQDGTINGQEIVEFMAPQFDREAVASAVETCKNPEGELVNDKIYAFGQCFFTKKTFEI
180 B4J5K8 Drosophila grimshawi Odorant binding 122 MPVSVADECLAKNNVTREDFLLRIDQSLAETHEENIEINYMCFVHCMATELNVLDANGRIDIELLQIVENLRDTNIEVVEECNRVNNSVEDLCIYAFEMLLCLIKNIDNTQYINIAPERADY
181 T1GB47 Megaselia scalaris Odorant binding 122 MKAFLVFAVILAVAVAEMHEMGEQFKGECMDQEKVDMSELKKVQLDDPTEKLKCFIRCLFEKGGFFKDGIFVDEKVKEFLNKQAQKEHMLAAYDDCKNIKGTNDCDTTFKMFLCMERAQFSH
182 A0A034WRT9 Bactrocera dorsalis Odorant binding 123 MKSFVTIALLVVGSAVVLCNPHDPEMRGYIEDCNKEHNVSPKDFHDFIEGKLTTVPENMKCSSQCIMVKQGIMDESGNFKPDAAKAKMKEDKLVAAVDECKDLSGSTPCDTAFKITSCMLSKK
183 A0A0A1XS85 Zeugodacus cucurbitae Odorant binding 123 MKSFITIALLVVYSVVVLCHPNDPEMRKFIEDCNKEHNVSPKDFHDFMEGKLTTVPESLKCSSHCIMVKQGVMDESGNFKADVAKAKITEEKFAAAIDECKDLTGSTPCDTAMKITECMITHK
184 A0A0K8W7T9 Bactrocera latifrons Odorant binding 123 MKSFVTIALLVVGSAVVLCNPNDPEMRGYIEDCNKEHNVSLKDFHDFMEGKLTTVPDNLKCSSQCIMVKQGIMDESGNFKPDVAKAKVKDDKLVAAVDGCKDLSGSTPCDTAFKITACMLSKK
185 A0A1D6Y6I9 Zeugodacus tau Odorant binding 123 MKSFITIALLVVYSVVVLCHPNDPEMRKFIEDCNKEHNVSPKDFHDFMEGKLTTVPESLKCSSHCIMVKQGVMDESGNFKADVAKAKITEEKFAAAIDECKDLTGSTPCDTAMKITECMIAHK
186 A0A1I8NJS3 Musca domestica Odorant binding 123 MVKQATVEPEIRAVVKFSVLTCAHDTNVPPQQAEHFMPEKSSLMENYTHDMKCFLLCFYRKMDLITYDDHPNHEAFASFMEKRFVSNKDRIKPALAKCLDIDDKDPCEEVYKFELCMLKNVQG
187 A0A1I8PGL2 Stomoxys calcitrans Odorant binding 123 MSEAKLKKVTEECMKQTGVSLEQANLIMKDELENVDEKDFSHNMRCYLHCYHLQMNLTEADGTPISSAYVKFMENRFANKKEKVIPALLKCQHVTDPDKCEFLFKFEMCMAHTIEGQGWEVTK
188 B4JXD1 Drosophila grimshawi Odorant binding 123 MMATEEQMWAAGKLMRDVCLPKFPKVSVAIADDIHEGRLPNDKDAKCYMNCVMEMMQTIKKGKFQLESSLKQVELLMPDHYKASYRRGLSECKDAGAGIKNNCDAAHALLTCFVGTIEIFIFP
189 D6WS39 Tribolium castaneum Odorant binding 123 MKFLVVISTVLMANIVQGLTDEQKSKLEEYSKECLKESKVDESVLKEAEKGVYLDDPKLMNHVYCLVKKINSQKDKGELEVTQIKEKLMMQINDEKEVDKLIQLCLVQEKSARYSLGKCEVSS
190 H9JKG0 Bombyx mori Odorant binding 123 MREKENEVRALRAFQADCAEDVQVKPDLVVNLKSGDWQTEDVSLKKWALCVLMKLGLMTAQGVFKMNEAMSKIPDMNDKIIAEKLIDDCLSLQATTPHDAAWNYIKCHHQKDPEGNFSSLNIF
191 T1GM01 Megaselia scalaris Odorant binding 123 MLKYIFVAVLICSQVFSEEFNISDHEELVKCAKELNLDLNDKDLMAKPEFKCIFKCAFEHEGLFKNGEVDSEKLVQVLISETDLDQNGKDIAIKKVPECLHKSRQVTDLCEKSFGIFECVFDM
192 A0A0L0C408 Lucilia cuprina Pheromone binding 124 AEVSKDEAMAIATSCKEETGASDADFETIIKHESAETQEGKCLLACFLKRVNVMDADGKMIKHAALEISESLISNDDERALVAEIIDICDDIDLSDEHCEAAFEYGECWKKEINSRGISTDHLV
193 A0A151WJV3 Trachymyrmex zeteki Odorant binding 124 MAKKSLILICASMILTQLVIVSCNEEDIDWSTVHDELRKLAGNLRKKCMGETGATNEMLDGAELGEFPTNDKTLSCYFKCVMEKGGAMKKDGKINYKILSKLMPQAYKHIGMEMIEQCRKIGKY
194 A0A1B0CHQ6 Lutzomyia longipalpis Odorant binding 124 MKSLVFLILFVTLSWASDIEDCAKETKLSDEELARFQKDDLTSEDPTAHCFVKCLLAKKNFFDDAGLPKKEVIAPYLRGLNPDKDVKEIMADCLKLIAEDGSGSCLTTYMRYKCSIQKGLVVLS
195 A0A212EMX4 Danaus plexippus plexippus Odorant binding 124 MKKWFLELTVECSKEHPVTKEEIQMLKDHKIPDNKNVKCLMGCVFRKIGWLDDNGMFSFNNAYKTSEEEYPDDKTKLEKAKNLYSLCEKVNTAEVSDGKEGCERSSLLAKCLIENSSKMGFVVQ
196 A0A232FG27 Trichomalopsis sacrophage Odorant binding 124 MKIFVIVALCAVAVYAEENEVLKRYERDCMTENGIDPTVQDPKNLTLEDGNCYYACYFKKFGIMKKDGSYDVAAIKEKYSKPNSVEAVQKKLDEITQTYCQDKAGNQCNLAACLSKISKEQWQI
197 B0WL17 Culex quinquefasciatus Odorant binding 124 MKFSLVLCLLPAVILAQDKLISREEETCREQEGASDEDVEMLQSFMTPETRTTKCYYSCVMQKIGYSDGQRFDKEGFLSTAVNFSSKDRETMQRIADQCEGTTNEDHCELAADIAECIIPSRRN
198 B0XK44 Culex quinquefasciatus Odorant binding 124 MRYSFVFIALTILASSCSGSMEQVKQACMEQEDVSQADADLFNKMDKPVTRPQKCFYACMFERFGTSDGHRFDTEVFLENSEKLAQNDQKMLNAAREMAERCDGVENEDRCELAADILNCLRGD
199 D2A674 Tribolium castaneum Odorant binding 124 MWSFVTLLFSFLVLASAQKKGKYWTTISECLTEHSMGVEDMKKFDLPAEKMSEEMLCFNKCFYDKLLITDENGEINTDNLMSIPLVNAIDASKHDDLVTCLKKVGKIEECDGVKKIEQCFVEFI
200 E2AD33 Camonotus floridanus Odorant binding 124 MYVHKMLPRLLYYIFAEKNRLQMISKTYYLSISIVVENAKNGQVAEGDEKLACFGNCILKKLGIINANGDIDWEVARSKVPPGISQEQIDHVYNKCQNVAGSGCEKGANLLKCFKENKNFAVLS
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