Odorant/Pheromone Binding Proteins

OBPs, members of lipocalin protein family, are highly diverse, small, water-soluble, globular, ligand specific proteins present in the mucus fluid produced by nasal glands in vertebrates and in the sensillar lymph in insects. OBPs act a “carrier” to transport odorants across the hydrophilic mucus layer and release them in vicinity of their respective ORs. OBPs are highly selective, as they have unique ligand binding profile. OBPs functionality and expression are not limited to olfaction mechanism and olfactory organs. They are found to be involved in various other functions like measuring odorant concentration, deactivating odorants, etc. and found in taste organs, venom glands, sex hormone glands, etc of insects. Structurally OBPs are made up of eight antiparallel β-sheets folded into a continuous hydrogen-bonded β-barrel and a α-helical domain at the carboxyl terminal. OlfactionBase comprises of 2418 Odorant binding proteins, 399 Pheromone Binding proteins and 14 receptors from 189 species.

obp
Sr. No UniProt Organism Type Length Sequence
851 OB99A Drosophila melanogaster Odorant binding 142 MKVFVAICVLIGLASADYVVKNRHDMLAYRDECVKELAVPVDLVEKYQKWEYPNDAKTQCYIKCVFTKWGLFDVQSGFNVENIHQQLVGNHADHNEAFHASLAACVDKNEQGSNACEWAYRGATCLLKENLAQIQKSLAPKA
852 Q52QW9 Agrotis ipsilon Pheromone binding 142 SQEVVASFSKGFTNVVEHCKAEVNAGEHIMQDIYNFWREEYQLVNRDLGCMVLCMANKLGLIGEDQKMHHAKAEEFAKSHGADEAVAKQLVAILYECETKHAAIEDECGMALEIAKCFRTKMHELKWAPSMEVAMEEIMTAV
853 Q5TN67 Anopheles gambiae Odorant binding 142 MGAFESGLGLLGWVAFGMVLLLAGRGCHAQDFKGAIDHCTKDFEMDMDIVVSLKYGDFTERDPLIECFTECLMKKSGFMYDDYTYNKTLIIGFAGRYLEPEGAQAVYDNCIDRFGQTVCVTGFEMYQCIHETAVSEWVSSNF
854 Q7Q9J3 Anopheles gambiae Odorant binding 142 MLFVFFTLLSCTKKKKIFPLRKSTVEQMMKSGEMIRSVCLGKTKVAEELVNGLRESKFADVKELKCYVNCVMEMMQTMKKGKLNYDASVKQIDTIMPDELAGPMRAALDICRTVADGIKNNCDAAYVLLQCLSKNNPKFIFP
855 Q7YT49 Agrotis ipsilon Pheromone binding 142 SQEVVASFSKGFTNVVEHCKAEVNAGEHIMQDIYNFWREEYQLVNRDLGCMVLCMANKLGLIGEDQKMHHAKAEEFAKSHGADEAVAKQLVAILYECETSTRPVEDECGWRLEIAKCFRTKMHELKWAPSMEVTMEEIMTAV
856 Q9GRH6 Spodoptera exigua Odorant binding 142 MTAEVMSHVTAHFGKALEECREESGLSAEVLEEFQHFWREDFEVVHRELGCAIICMSNKFSLLQDDTRMHHVNMHDYVKGFPNGHVLSEKLVELIHNCEKRFDSMTDDCERVVKVAACFKVDAKAAGIAPEVAMIEAVMEKY
857 Q9TWY7 Antheraea pernyi Pheromone binding 142 SPEIMKNLSNNFGKAMDQCKDELSLPDSVVADLYNFWKDDYVMTDRLAGCAINCLATKLDVVDPDGNLHHGNAKDFAMKHGADETMAQQLVDIIHGCEKSAPPNDDKCMKTIDVAMCFKKEIHKLNWVPNMDLVIGEVLAEV
858 Q9U9J5 Apis mellifera Odorant binding 142 MNTLVTVTCLLAALTVVRGIDQDTVVAKYMEYLMPDIMPCADELHISEDIATNIQAAKNGADMSQLGCLKACVMKRIEMLKGTELYVEPVYKMIEVVHAGNADDIQLVKGIANECIENAKGETDECNIGNKYTDCYIEKLFS
859 S5R7I3 Bactrocera dorsalis Odorant binding 142 MNTQLILLLACVALVAGKFQIRTAQDALDAHEACHEEYRVPEDIYQKFLNYEFPAHKRTNCYVKCFVERMGLFTEEKGFDEKAIIAQFTAKSSKNLAKVSHGLEKCLDHNEHDSDTCTWANRVFSCWISVNRPIVRRTYIEN
860 A0A034WWC1 Bactrocera dorsalis Odorant binding 143 MKYFMLIVILAVVALVQADDWSPKTVDDIKKIREECMKQVPSSDEEFQKRKENDYPDVESVRKYALCNSKGWGLYKESKGFYPDRVAEQFKDDMPEDEIKAIVNDCDEKTKEETDDERCYHLLKCVMSTKLGDHIKDLVKRLE
861 A0A084VE38 Anopheles sinensis Odorant binding 143 MKFIAVVSLFLAFAYASVKADEVDDAKEMLRGLASDCKAKEGASDDDVDGFVNDVPPKTRTEKCLVACMQEQFGVSNGKTFQVEGFLELSKVLMKGDDSKMETAKEIADDCKAMANDDRCELAVDILNCLKDSAEKHGIELKH
862 A0A088AP24 Apis mellifera Odorant binding 143 MHVKSVFLLITIVTFVALKPVKSMSADQVEKLAKNMRKSCLQKIAITEELVDGMRRGEFPDDHDLQCYTTCIMKLLRTFKNGNFDFDMIVKQLEITMPPEEVVIGKEIVAVCRNEEYTGDDCQKTYQYVQCHYKQNPEKFFFP
863 A0A0A1WH84 Zeugodacus cucurbitae Pheromone binding 143 MKYFVVSLVICSLVMSYSEAQELPMRLKKIVEECKARLGAGDDDVAAMFKYEPATNKQVKCLHACTMRLLGILDKNNKPFEAGAMAYIKSVTASNAELEKLLTEVYNECKYFPASKEGCEFSEAFRVCIIERSRAKGIHMLLH
864 A0A0A1X2M0 Zeugodacus cucurbitae Pheromone binding 143 MKYFVVCLAIFSLVISHTEAQELLEKIKQIAEECKGQVGASDDDVTRMLKYEPATNDKAKCLQACIMKQFGILDDNNKLVEAGAMAYIKSLAAGDAELEKLSTEVYNECKNTPASSNECEYAEAVRVCTIENSKSKGIKILPQ
865 A0A0K8WLU2 Bactrocera latifrons Odorant binding 143 MKYIVAVLLAALVAMAAAEEYKIRNQDDLLKARKECMEAKKVPTEHIEKFKKFEFPDDEVTRCYIECIFNKFQLFSPTEGFKTQNLIAQLGQNKENKDAVKADIEKCADKNEQKSDSCTWAYRGFKCFISKNLPLVQESLKKN
866 A0A0L0CEM7 Lucilia cuprina Odorant binding 143 MVKIILLILSWTLMSIRAEKPSWLPENADNIPTKCYEENQLKPFFDKDLPYDQLVNNTKLHNVLLCQLKAFNIYSEETGLNVDRFPYAFGLNEINCVKSFVQDCVDTHKAVASAGEMILKVSHCTWDKISEYKKSVHVNTDDC
867 A0A0M3QZL9 Drosophila busckii Odorant binding 143 MLHYHLLMLNCLLLGLPAAWSGATEEQMRAAGKLMRDVCFPKFSKVSEDMANAISNGNLLDDKDSKCYINCIMEMMQTMKKGKFQMESSLKQVDLLMPDEYKPSYRVGIAECKDVSNGIKNNCEASYTMLTCLKQKIPIFLFP
868 A0A0M4EHI5 Drosophila busckii Odorant binding 143 MQRFVYSLALVALLGAALVRAFDEKDALAKFMEYAEPCKTEVGANANDVEEAVKHVPASTKEGRCLRACIMKKFGLMNSNGKLDTDAGHEKAKQYTGNDPAKLAIALEIGDICAAIPVPDDHCEAAEAYGKCFMTEAKNHGLV
869 A0A0M8ZV09 Melipona quadrifasciata Odorant binding 143 MHAKLLFVATLFALVAWKPAESLSQEQMNKMAKNMRKSCMQKIDVLEDKVEGMRRGEFPSDDQNLKCYTTCIMKTLRTFKNGEIDFGMVIKQIDLTMPPESASLVKEVVNTCQKLEYTGDDCNKTYELIKCYYFTNPELFLFP
870 A0A151I5M0 Atta colombica Pheromone binding 143 MHVSVILGVVLLQAIYVSAGPPDWIPAEMLEMVQADKERCMAEHGTSQVLIDEVNDGKLSNDRSITCYMNCLLDAFSLVDEEGNLEADMLISVIPEQFQEIGNKILNKCAKQDGADACEKIYEVAKCVQGTVPEVNGFIVSNQ
871 A0A151I6L5 Cyphomyrmex costatus Pheromone binding 143 MHVSVILGVVLLQAIYVSAGPPDWIPAEMLEMVQADKERCMSEHGTSQVLIDEVNDGKLSNDRSITCYMNCLLDAFSLVDEDGNLEADMLISVIPEQFQEIGTKILNKCAKQDGADACEKIYEIAKCVQGTVPEVNRFIISSQ
872 A0A151JYK2 Trachymyrmex septentrionalis Pheromone binding 143 MHVPVILGVVLLQAIYVSAGPPDWIPAEMLEMVQADKERCMAEHGTSQVSIDEVNDGKLSNDRSITCYMNCLLDAFSLVDEEGNLEADMLISVIPEQFQEIGNKILNKCAKQDGADACEKIYEVAKCVQGTVPEVNRLIVSSQ
873 A0A151X4D2 Trachymyrmex zeteki Pheromone binding 143 MHVSVILGVVLLQAIYVSAGPPDWIPAEMLEMVQADKERCMAEHGTSQVLIDEVNDGKLSNDRAITCYMNCLLDAFSLVDEEGDLEVDMLISVIPDQFQEIGNKILNKCAKQDGADACEKIYEVAKCVQGTVPEVSRFIISSQ
874 A0A172BZK6 Zeugodacus tau Odorant binding 143 MKYIVAVLLAALVAMAAAEEYKIRNQDDLLKARKECMEAKKVPTEHIEKFKKFEFPDDEVTRCYIECIFNKFQLFSPTEGFKTQNLIAQLGQNKENKDAVKADIEKCADKNEQKSDSCTWAYRGFKCFISKNLPLVQESLKKN
875 A0A172BZK8 Zeugodacus tau Odorant binding 143 MKYFVVCLAICSLVIAHTEAQELLEKVKQIAEECKGQVGASDDDVTRMLKYEPATNDKAKCLQACIMKQFGILDDNNKLVEAGAMAYIKSLAAGDAELEKLSTEVYNECKNTPASSNECEYAEAVRVCTIENSKSKGIKLLPQ
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